pentobarbital raises toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. CYP3A4 inducers may perhaps increase the metabolism of ifosfamide to its Lively alkylating metabolites.
pentobarbital will decrease the level or impact of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Advisable atogepant dosage with concomitant usage of solid or moderate CYP3A4 inducers is thirty mg or sixty mg qDay.
pentobarbital will decrease the extent or effect of almotriptan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
The onset of motion for oral or rectal administration may differ from twenty to sixty minutes. For IM administration, the onset of action is somewhat more quickly. Following IV administration, the onset of action ranges from presently for pentobarbital sodium to five minutes for phenobarbital sodium.
The normal each day dose to the barbiturate addict is often about 1.5 grams. As tolerance to barbiturates develops, the quantity wanted to maintain exactly the same volume of intoxication will increase; tolerance to some lethal dosage, nonetheless, doesn't maximize in excess of two-fold. As this occurs, the margin among an intoxicating dosage and lethal dosage will become more compact.
pentobarbital will lessen the extent or impact of elagolix by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
Griseofulvin: Phenobarbital appears to interfere Using the absorption of orally administered griseofulvin, As a result reducing its blood level.
pentobarbital will increase the amount or result of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will reduce the extent or influence of estropipate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital boosts consequences of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Warning/Check. Coadministration of ifosfamide with CYP2B6 inducers could maximize metabolism of ifosfamide to its metabolite. Keep track of for enhanced consequences/toxicities if coupled with CYP2B6 inducers.
pentobarbital will lessen the level or impact of alosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.
Phenobarbital sodium is carcinogenic in mice and rats soon after life time administration. In mice, it developed benign and malignant liver cell tumors. In rats, benign liver cell tumors have been noticed very late in everyday life.
pentobarbital will decrease the level or outcome of bosentan by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Mysterious.
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